Precision (Individualized) Dosing

Balancing the benefits and risks of therapies is critical. A key to achieving this balance is identifying the dose at which efficacy is maximized and toxicity and adverse events is minimized.

Precision(Individualized) dosing is a next generation dosing paradigm in which our Clinical Pharmacology group is using mathematical models for drugs and diseases, in combination with individual patient demographics (e.g. genotype, organ function, body-weight), disease characteristics (e.g. drug target expression, pathogen susceptibility, disease activity) and measured drug concentration and response to treatment, to calculate the optimal dose for each patient.

Model-informed precision dosing allows integration of all available knowledge on a drug in a mathematical model and to use this to inform individual treatment in order to increase efficacy and decrease safety issues. Model-informed precision dosing may become standard of care for certain drugs with narrow therapeutic index by use of companion dosing tools.