Providing Patients Flexibility and Convenience
Some dosing strategies are geared towards optimizing the drug label after several years of experience in the real world setting, giving better safety and more convenience to patients, therefore improving adherence to the therapy. Several example include
Tailored Dosing Regimen for Reducing Adverse Events and Burden to Patients
Drugs with a large therapeutic index are generally administered as a flat dose and usually the same dose is administered to all patients. However we keep improving the benefit to patients by optimizing the use of those molecules: by better managing safety and reducing treatment burden.
ERIVEDGE (vismodegib)
More convenient route of administration
(2a) Subcutaneous (SC) Injections instead of Intravenous Injections (which requiring an infusion chair in a doctor’s office).
HERCEPTIN SC
(2b) Extending Delivery by Means of a Delivery Device
For our ocular medicines, since frequent ITV injection places a high treatment burden on patients and care-givers, a sustained delivery option is desired. The Port Delivery System (PDS) is such a device that is being explored for ranibizumab and other ITV administered medicines
LUCENTIS (ranibizumab)
Allowing flexible dosing interval
Oncology treatments, especially immunotherapy are meant to be administered in combination therapy with various partners administered according to different cycle lengths. Having the possibility to adjust the dosing interval to combination partners helps to reduce the burden to patients. It can also help to better manage the tolerability of the treatment.
TECENTRIQ (atezolizumab)
